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Title   유방암 환자의 혈액 및 암조직에서 생물학적 치료의 Target 으로서 Urokinase-type Plasminogen Activator ( uPA ) , uPA Receptor , Plasminogen Activator Inhibitor-1 의 발현 ( Clinical Relevance of Urokinase-type Plasminogen Activator ( uPA ) , uPA Receptor , Plasminogen Activator Inhibit
Publicationinfo   1999 Jan; 031(02): 256-267.
Key_word   uPA, uPAR, PAI-1, Breast cancer, Tissue, Blood
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Abstract   Purpose: We measured and compared the uPA, plasminogen activator inhibitor-1 (PAI-1) and uPA receptor (uPAR) levels in breast cancer tissues and blood of the patients to evaluate their clinical relevance for biotherapy. Materials and Methods: uPA, PAI-1 (Monozyme, Netherland), uPAR (American Diag- nostics, USA) levels were measured by ELISA assay in 192 breast cancer tissues, in 18 normal breast tissues and in 163 blood from breast cancer patients. Results: There was a tendency of uPA increment from ductal carcinoma in situ while increment of PAI-1 and uPAR occurred from Ti. With the progression of cancer, uPA, PAI-1, uPAR tended to decrease; however, the uPA/uPAR, uPA/PAI-1 ratios remained unchanged. There was a correlation of uPA expression between normal and cancer tissues ( r(2)= 0.49). Correlation of uPA and PAI-1 was found in normal tissue and stage I cancer tissue while correlation of uPAR and PAI-1 was found with cancer progression. Between cancer tissue and blood significant correlations were found in uPA, PAI-1, uPAR levels. Conclusion: uPA, PAI-1, uPAR levels in cancer tissue elevated from the early stage maintaining correlative expressions with cancer progression. A positive correlation between cancer tissue and blood level suggested the applicability of the levels of uPA, PAI-1 or uPAR for detecting patients for biotherapy.
저 자   라선영(Sun Young Rha),박준오(Joon Oh Park),공수정(Soo Jung Gong),박세호(Se Ho Park),유내춘(Nae Choon Yoo),양우익(Woo Ick Yang),노재경(Jae Kyung Roh),민진식(Jin Sik Min),이경식(Kyong Sik Lee),김병수(Byung Soo Kim),정현철(Hyun Cheol Chung)